Transcription of Dissolution Testing of a Controlled- Release Capsule ...
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6 Dissolution Technologies | MAY 2013 Dissolution Testing of a Controlled- Release Capsule formulation : challenges and solutions Using a Semi-Automated Dissolution SystemLili Lo, Xujin Lu*, and David LloydAnalytical and Bioanalytical Development, Bristol-Myers Squibb, New Brunswick, NJ 08903 ABSTRACTA Controlled- Release formulation was developed using enteric-coated beads in a hard gelatin Capsule shell. This formulation requires two-stage Dissolution Testing at low and neutral pH. Because of high toxicity and limited stability of the active phar-maceutical ingredient in aqueous solution at room temperature, it is preferable to limit the analyst s contact with the sample solutions during Testing , and aliquots from the Dissolution vessel need to be quickly filtered and refrigerated immediately after sampling.
6 Dissolution Technologies | MAY 2013 Dissolution Testing of a Controlled-Release Capsule Formulation: Challenges and Solutions Using a …
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Chapter 30 PHARMACEUTICAL, Chapter 30 PHARMACEUTICAL PRODUCTS, Waters, Pharmaceutical, SYLLABI OF BACHELOR OF PHARMACEUTICAL, SYLLABI OF BACHELOR OF PHARMACEUTICAL SCIENCES FIRST, Guide, Solid Phase Extraction, Separating beyond question, MANUFACTURING PRACTICES:, Manufacturing practices: water for pharmaceutical, American Society of Pharmacognosy Annual, American Society of Pharmacognosy Annual Meeting