Transcription of DRUG NAME: Afatinib
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DRUG NAME: Afatinib
Afatinib drug name : Afatinib SYNONYM(S): Afatinib dimaleate1, BIBW29922 COMMON TRADE name (S): GIOTRIF , GILOTRIF (USA) CLASSIFICATION: miscellaneous Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Afatinib is a second-generation tyrosine kinase It binds to the kinase domains of EGFR, HER2 and HER4, irreversibly inhibiting tyrosine kinase autophosphorylation, and results in reduction of tumour growth and tumour ,4 Afatinib has activity against tumours that overexpress wild-type EGFR or HER2, and those having EGFR mutations ( , exon 19 deletion or exon 21 substitution).
has been reported in 96% of patients receiving afatinib. Onset of diarrhea usually occurs within the first 2 weeks of treatment, with grade 3 diarrhea developing most frequently within the first 6 weeks.
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