Transcription of DRUG NAME: Bleomycin
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DRUG NAME: Bleomycin
Bleomycin BC Cancer Agency Cancer Drug Manual Page 1 of 10 Bleomycin Developed: September 1994 Revised: 1 May 2007 Limited Revision: 1 March 2009, 1 June 2013, 1 December 2014 DRUG NAME: Bleomycin SYNONYM(S): NSC-125066;1 BLM ; Bleo COMMON TRADE NAME(S): BLENOXANE , generic available CLASSIFICATION: Antitumour antibiotic Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Bleomycin causes DNA strand scission through formation of an intermediate metal complex requiring a metal ion cofactor such as copper or This action results in inhibition of DNA synthesis, and to a lesser degree, in inhibition of RNA and protein The drug is cell-cycle specific for G phase, M-phase and S PHARMACOKINETICS: Interpatient variability no information found Distribution mainly in the skin, lungs, kidneys, per
A cumulative dose of greater than 450 units of bleomycin is also a known risk factor for developing BPT. Carcinogenicity: Bleomycin is carcinogenic in animals. ... were reported in more than 1% of patients in the product monograph or pivotal trials, and/or determined to be clinically important. ORGAN SITE SIDE EFFECT . Clinically important side ...
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