Transcription of DRUG NAME: Mitomycin
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DRUG NAME: Mitomycin
Mitomycin DRUG NAME: Mitomycin SYNONYM(S): Mitomycin C,1 MMC1. COMMON TRADE NAME(S): MUTAMYCIN . CLASSIFICATION: antitumour antibiotic Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: 2. Mitomycin is derived from Streptomyces caespitosus and has antineoplastic activity similar to that of the alkylating 3 2,3. agents. Mitomycin selectively inhibits the synthesis of DNA by causing cross-linking, degrades preformed DNA, 4. and causes nuclear lysis and formation of giant cells. At high concentrations, cellular RNA and protein synthesis 2,3. may also be suppressed.
Corticosteroids have been reported to help with symptoms but their therapeutic value has not been determined. 1,3: ... of mitomycin has been used for intravesical administration. 9,15-17; to prevent precipitation, solution should be freshly prepared and not refrigerated. 18.
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