Transcription of DRUG NAME: Mitomycin - bccancer.bc.ca
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DRUG NAME: Mitomycin - bccancer.bc.ca
Mitomycin DRUG NAME: Mitomycin SYNONYM(S): Mitomycin C,1 MMC1. COMMON TRADE NAME(S): MUTAMYCIN . CLASSIFICATION: antitumour antibiotic Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: 2. Mitomycin is derived from Streptomyces caespitosus and has antineoplastic activity similar to that of the alkylating 3 2,3. agents. Mitomycin selectively inhibits the synthesis of DNA by causing cross-linking, degrades preformed DNA, 4. and causes nuclear lysis and formation of giant cells. At high concentrations, cellular RNA and protein synthesis 2,3. may also be suppressed. Mitomycin is cell cycle phase-nonspecific, although it has its maximum effect in late G- 4. and early S-phases. PHARMACOKINETICS: Oral Absorption no information found 2,3.
To achieve a 0.2 mg/mL (0.02%) eye drop solution: • Reconstitute 5 mg vial of mitomycin with 10 mL SWI to give a concentration of 0.5 mg/mL.
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