DRUG NAME: Paclitaxel

Paclitaxel DRUG name : Paclitaxel synonym (S): benzenepropanoic acid1 common trade name (S): TAXOL , ONXOL CLASSIFICATION: antimicrotubule agent Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Paclitaxel is a taxane. Paclitaxel binds to tubulin, the protein component of microtubules, simultaneously promoting their assembly and disassembly to form stable, nonfunctional ,2 Although some reports indicate a cross-reactivity rate of 90% between docetaxel and Paclitaxel , others suggest it does not occur ,3 Stabilization of microtubules blocks cells in the M phase of the cell cycle, inhibiting cell division and causing cell Paclitaxel acts as a radiosensitizing agent by blocking cells in the Paclitaxel is an ,6 PHARMACOKINETICS: Oral Absorption no information found Distribution biphasic: initial distribution to peripheral compartment, then slow efflux from the peripheral compartment.

DRUG NAME: Paclitaxel SYNONYM(S): benzenepropanoic acid1. COMMON TRADE NAME(S): TAXOL ®, ONXOL. CLASSIFICATION: antimicrotubule agent. Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Paclitaxel is a taxane.

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