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DRUG NAME: Pazopanib

Pazopanib BC Cancer Agency Cancer drug Manual Page 1 of 7 Pazopanib Developed: 1 October 2011 Revised: 1 October 2015 drug name : Pazopanib SYNONYM(S): Pazopanib hydrochloride, GW7860341 COMMON TRADE name (S): VOTRIENT CLASSIFICATION: vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Pazopanib is an orally active tyrosine kinase inhibitor of vascular endothelial growth factor receptor (VEGFR-1,-2, -3), platelet-derived growth factor receptor (PDGFR- ,- ), and stem cell factor receptor (c-KIT).2 Similar to sunitinib or sorafenib, Pazopanib is reported to block tumour growth by interfering with angiogenesis.

Pazopanib BC Cancer Agency Cancer Drug Manual© Page 1 of 7 Pazopanib Developed: 1 October 2011 Revised: 1 October 2015 DRUG NAME: Pazopanib SYNONYM(S): pazopanib hydrochloride, GW7860341 COMMON TRADE NAME(S):

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