Transcription of DRUG NAME: Tamoxifen
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DRUG NAME: Tamoxifen
Tamoxifen DRUG NAME: Tamoxifen SYNONYM(S): Tam, Tamoxifene COMMON TRADE NAME(S): NOLVADEX-D , TAMOFEN CLASSIFICATION: endocrine anti-hormone Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Tamoxifen and several of its metabolites are thought to act as estrogen antagonists, by competitively binding to estrogen receptors on tumour and other tissue targets, producing a nuclear complex that decreases DNA ,2 This mechanism appears to have cytostatic effects, causing cells to accumulate in G0 and G1 Tamoxifen may also have cytotoxic activity.
Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Tamoxifen and several of its metabolites are thought to act as estrogen antagonists, by competitively binding to estrogen receptors on tumour and other tissue targets, producing a nuclear complex that decreases DNA synthesis. 1,2
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