Transcription of DRUG NAME Temozolomide - BC Cancer
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DRUG NAME Temozolomide - BC Cancer
Temozolomide DRUG NAME: Temozolomide SYNONYM(S): TMZ, , NSC 362856. COMMON TRADE NAME(S): TEMODAL , TEMODAR . CLASSIFICATION: Alkylating agent Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Temozolomide undergoes rapid chemical conversion at physiologic pH to the active compound , monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is thought to be due primarily to methylation of 6 1,2. DNA at the O position of guanine. Both Temozolomide and dacarbazine are prodrugs of MTIC. Unlike dacarbazine, Temozolomide does not require metabolic activation by the cytochrome P450.
Temozolomide undergoes rapid chemical conversion at physiologic pH to the active compound, monomethyl triazeno imidazole carboxamide (MTIC). ... Temozolomide capsules have been used for the extemporaneous compounding of an oral suspension. 28. ... Guidelines for dosing also include consideration of absolute neutrophil count (ANC). Dosage may be ...
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