Transcription of DRUG NAME: Thiotepa
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DRUG NAME: Thiotepa
Thiotepa DRUG NAME: Thiotepa SYNONYM(S): TESPA,1 TSPA1 COMMON TRADE NAME(S): CLASSIFICATION: alkylating agent Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Thiotepa , a derivative of nitrogen mustard, acts as a polyfunctional alkylating Alkylation takes place through the formation of a highly reactive ethylenimine This radical likely forms a cross-linkage between two strands of DNA,2 interfering with DNA, RNA, and protein ,3 These actions do not appear to be cell cycle phase-specific. Thiotepa has immunosuppressive Intracavitary (intra-pleural, -pericardial, and -peritoneal) administration of Thiotepa also produces an inflammatory reaction on serous membranes with a resulting sclerosing PHARMACOKINETICS: Oral Absorption variable as unstable in acidic pH; therefore, not administered orally peak plasma concentrations occur immediately; lipid-soluble,4 variable absorption occurs throug
peak plasma concentrations occur immediately; lipid-soluble, 4: variable absorption occurs through serous membranes and from IM …
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