Transcription of DRUG NAME: Thiotepa
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DRUG NAME: Thiotepa
Thiotepa drug NAME: Thiotepa SYNONYM(S): TESPA,1 TSPA1 COMMON TRADE NAME(S): CLASSIFICATION: alkylating agent Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Thiotepa , a derivative of nitrogen mustard, acts as a polyfunctional alkylating Alkylation takes place through the formation of a highly reactive ethylenimine This radical likely forms a cross-linkage between two strands of DNA,2 interfering with DNA, RNA, and protein ,3 These actions do not appear to be cell cycle phase-specific. Thiotepa has immunosuppressive Intracavitary (intra-pleural, -pericardial, and -peritoneal) administration of Thiotepa also produces an inflammatory reaction on serous membranes with a resulting sclerosing PHARMACOKINETICS: Oral Absorption variable as unstable in acidic pH; therefo
Thiotepa DRUG NAME: Thiotepa SYNONYM(S): TESPA, 1 TSPA 1. COMMON TRADE NAME(S): CLASSIFICATION: alkylating agent. Special pediatric considerations are noted when applicable, otherwise adult provisions apply.
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Oral Cancer Drug Therapy Safe Use and Safe, Oral cancer drug, British Columbia Cancer Agency POLICY, Hazardous Drug Safe Handling Standards, Cancer, Therapy, Safe, Safe Prescribing, Handling and Administration of, Product Monograph, Oral, Drug, Against Cancer, Drug Management and Prior Authorization, Supporting Continuity of Care for Cancer