Transcription of DRUG NAME: Thiotepa
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DRUG NAME: Thiotepa
Thiotepa DRUG NAME: Thiotepa SYNONYM(S): TESPA,1 TSPA1 COMMON TRADE NAME(S): CLASSIFICATION: alkylating agent Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Thiotepa , a derivative of nitrogen mustard, acts as a polyfunctional alkylating Alkylation takes place through the formation of a highly reactive ethylenimine This radical likely forms a cross-linkage between two strands of DNA,2 interfering with DNA, RNA, and protein ,3 These actions do not appear to be cell cycle phase-specific.
Other uses: *Bladder cancer (intravesical) *Breast cancer . Malignant meningeal neoplasms: 1,11 (intrathecal) High-dose for myeloablation prior to bone marrow transplant. 9 *Intracavitary effusions secondary to malignancy
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