Transcription of DRUG NAME: Vinorelbine
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DRUG NAME: Vinorelbine
Vinorelbine BC Cancer Agency Cancer Drug Manual Page 1 of 8 Vinorelbine Developed: September 1994 Revised: 2001 Limited Revision: 1 March 2008, 1 February 2015 DRUG NAME: Vinorelbine SYNONYM(S): Vinorelbine tartrate, VRL, VNL, NVB COMMON TRADE NAME(S): NAVELBINE CLASSIFICATION: Mitotic inhibitor Special pediatric considerations are noted when applicable, otherwise adult provisions apply. MECHANISM OF ACTION: Vinorelbine is a semisynthetic vinca alkaloid derived from vinblastine. Vinca alkaloids such as vincristine and vinblastine are originally derived from periwinkle leaves (vinca rosea).1 Vinorelbine inhibits cell growth by binding to the tubulin of the mitotic Like other mitotic inhibitors, Vinorelbine also promotes apoptosis in cancer In vitro Vinorelbine shows both multidrug and non-multidrug Microtubules are present in mitotic spindles, neuronal axons, and other cells.
Vinorelbine is a semisynthetic vinca alkaloid derived from vinblastine. Vinca alkaloids such as vincristine and vinblastine are originally derived from periwinkle leaves (vinca rosea). 1. Vinorelbine inhibits cell growth by binding to the tubulin of the mitotic microtubules. 2. Like other mitotic inhibitors, vinorelbine also promotes apoptosis ...
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