Transcription of drugINTERACTIONS: insights and observations Get …
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drugINTERACTIONS: insights and observations Get …
The cytochrome p450 enzymesare found primarily in the liver,although some (eg, CYP3A4) arealso found in substantial amounts inthe intestine. They are involved in themetabolism of most medications andare the mechanism by which mostpharmacokinetic drug interactionsoccur. Cytochrome p450 3A4 (CYP3A4)is the superstar;it gets attentionbecause a majority of drugs are metab-olized by importantCYP450 enzymes include CYP1A2,CYP2C9,CYP2C19,and will focus on a rising star: SubstratesThe importance of CYP1A2 for druginteractions has been increasing overthe past decade due to the growingnumber of drugs metabolized by metabolized by CYP1A2are called CYP1A2 InhibitorsDrugs that inhibit CYP1A2 will pre-dictably increase the plasma concen-trations of the medications listed inTable 1, and in some cases adverseoutcomes will occur.
T he cytochrome P450 enzymes are found primarily in the liver, although some (eg, CYP3A4) are also found in substantial amounts in the intestine. They are involved in the
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