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HIGHLIGHTS OF PRESCRIBING INFORMATION ...

HIGHLIGHTS OF PRESCRIBING INFORMATION -----------------------------CONTRAINDIC ATIONS------------------------------ These HIGHLIGHTS do not include all the INFORMATION needed to use Known hypersensitivity to apremilast or any excipients in formulation (4). OTEZLA safely and effectively. See full PRESCRIBING INFORMATION for OTEZLA. -----------------------WARNINGS AND PRECAUTIONS----------------------- Diarrhea, Nausea, and Vomiting: Consider OTEZLA dose reduction or OTEZLA (apremilast) tablets, for oral use suspension if patients develop severe diarrhea, nausea, or vomiting. ( ). Initial approval: 2014 Depression: Advise patients, their caregivers, and families to be alert for the emergence or worsening of depression, suicidal thoughts or other mood ---------------------------RECENT MAJOR CHANGES--------------------------- changes and if such changes occur to contact their healthcare provider.

HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use OTEZLA safely and effectively. See …

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