EAACI/GA2LEN guideline: aspirin provocation tests for ...

Review articleEAACI/GA2 LEN guideline: aspirin provocation tests fordiagnosis of aspirin hypersensitivityAspirin and other nonsteroidal anti-inflammatory drugs(NSAIDs) are among the most common causes of adversedrug reactions (1). Majority of them are of the hyper-sensitivity two frequent clinical presentations of aspirinhypersensitivity are: aspirin -induced bronchial asthma/rhinosinusitis (AIA/R) and aspirin -induced urticaria/an-gioedema (AIU). Recent data point to emerging basicsimilarities at the biochemical level between these twodistinct clinical syndromes (2). It was proposed 30 yearsago that aspirin -precipitated reactions result from inhibi-tion of cyclooxygenase (COX) by aspirin -like drugs in theairways or in the skin of the hypersensitive patients (3).

Drug withdrawal before oral aspirin challenge procedures: Short-acting b 2-agonists 6 h (8 h, if possible) Ipratropium bromide 6 h (8 h, if possible) Long-acting b 2-agonists 24 h (48 h, if possible) Long-acting theophilline 24 h (48 h, if possible)

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  Guidelines, Tests, Aspirin, Eaaci, Provocation, Eaaci ga2len guideline, Ga2len, Aspirin provocation tests

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