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EDUCATIONAL COMMENTARY – BLEEDING DISORDERS: …

EDUCATIONAL COMMENTARY BLEEDING DISORDERS: hemophilia AND VON WILLEBRAND DISEASE EDUCATIONAL COMMENTARY is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain FREE CME/CMLE credits, click on Earn CE Credits under Continuing Education on the left side of the screen. Learning Outcomes On completion of this exercise, the participant should be able to identify laboratory tests used to diagnose BLEEDING disorders; discuss the pathogenicity of hemophilia and von Willebrand disease (VWD); analyze coagulation results to distinguish VWD from hemophilia ; and describe currently available treatments. Introduction Diagnosing a BLEEDING disorder requires a multidisciplinary approach. Several tools are utilized before laboratory testing. The first assessment is a complete family history, which includes age when BLEEDING started, medications, information on additional family members with BLEEDING symptoms, and location and type of All of this information will help determine if the disorder is acquired or congenital.

level of FIX. Hemophilia has been traced through three generations the royal families of England, Germany, Spain,and eventually to Tsar Nicolas II’s son Alexei, who was known to have the disorder.7 Recently, DNA analysis confirmed this to be hemophilia B (FIX deficiency).

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