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Effects of Epinephrine in Local Anesthetics onthe Central and Peripheral Nervous Systems:Neurotoxicity and Neural Blood FlowJoseph M. Neal, has been combined with neuraxialand peripheral Local Anesthetics since HeinrichBraun first experimented with its use as a chemicaltourniquet in the early century of useattests to the general safety of adjuvant epineph-rine, yet we have only modest understanding of itsintended Effects , which include prolonging blockduration, reducing plasma concentration of localanesthetics, reducing surgical bleeding, and inten-sifying anesthesia and long-heldbelief that Epinephrine exerts most of these Effects ,including any associated complications, by causingvasoconstriction is doubtlessly too simplistic andhas been recently challenged.
Effects of Epinephrine in Local Anesthetics on the Central and Peripheral Nervous Systems: Neurotoxicity and Neural Blood Flow Joseph M. Neal, M.D.
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