Transcription of Encapsulation - particlesciences.com
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Encapsulation - particlesciences.com
2010 Particle Sciences, Inc. All rights from a vibrating nozzle yields particles with a very narrow size ProcessesFor water-insoluble APIs, the API/excipient/solvent solution can be emulsified into an aqueous surfactant solution using industry-standard emulsification equipment such as overhead paddle mixers, rotor-stator homogenizers and in-line static mixers. Precise control of droplet size can be achieved with emulsification techniques such as tangential-flow membrane (TFM) emulsification2, microfluid-ics and vibrating nozzles. Emul-sions are made by TFM by for- cing the organic phase through the pores of a membrane separating it from a tangentially flowing aque-ous emulsifier phase. Flow-rates and pore size, shape, angle, and surface-chemistry control the drop-let size and distribution. Vibrating nozzles and microfluidic devices EncapsulationIntroductionActive pharmaceutical ingredi-ents (APIs) are often administered as aqueous solutions or suspen-sions, and pharmacokinetics are primarily determined by drug concentration or particle size, re-spectively.
can also form particles with a very narrow size distribution. In all emulsion-based processes, the organic solvent must be relatively
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