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EP28-A3c: Defining, Establishing, and Verifying Reference ...

October 2010EP28-A3cDefining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline Third EditionThis document contains guidelines for determining Reference values and Reference intervals for quantitative clinical laboratory guideline for global application developed through the Clinical and Laboratory Standards Institute consensus process. SAMPLEC linical and Laboratory Standards InstituteSetting the standard for quality in clinical laboratory testing around the Clinical and Laboratory Standards Institute (CLSI) is a not-for-profit membership organization that brings together the varied perspectives and expertise of the worldwide laboratory community for the advancement of a common cause: to foster excellence in laboratory medicine by developing and implementing clinical laboratory standards and guidelines that help laboratories fulfill their responsibilities with efficiency, effectiveness, and global applicability.

health-associated reference values as they relate to quantitative clinical laboratory tests. Included are various requirements for studies to determine reference values for a new analyte or a new analytical method of a previously measured analyte. Also discussed is the transfer of established reference values from one laboratory to another.

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