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EPIGENETICS COURSERA CLASS: LECTURE WEEK 1

EPIGENETICS COURSERA class : LECTURE week 1 ~25,000 genes in humans but not all are used at same time in all cells. EPIGENETICS is concerned with this regulation. It is the comments and import statements in the code base of DNA. ~1000 genes are involved in epigenetic control Terminology: DNA wrapped around histones forms chromatin more than 2 meters of DNA in each nucleus => packed into 10 micrometer of nucleus nucleosome is the smallest unit of chromatin, made up of ~8 histones positively charged histones + negatively charged DNA => attract nucleosomes are like beads on the string chromatin can be tightly ( Hetrochromatin ) or less tightly ( Euchromatin ) packaged => controls accessibility of DNA to transcription factors, RNA polymerase chromatin packaging forms higher order structure in 30nm fibre.

epigenetics coursera class: lecture week 2 ­ Acetylation or Methylation (among other things) can happen at N­terminal tails of histones. ­ Various molecules can bind to histones, some suggest there is a “histone code”, as these all

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