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Establishing MIC breakpoints and the …
Updated 2005 January 2005 1 Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests Alasdair P. MacGowana* and Richard Wiseb aDepartment of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB; bDepartment of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK Corresponding author: Tel: 0117 959 5652; Fax: 0117 959 3154; Email: The purpose of undertaking susceptibility testing, by whatever method, is to attempt to integrate the drug potency against a population of potential pathogens with the pharmacokinetics of the antimicrobial and, whenever possible, to review this relationship in the light of clinical experience following therapy in clinical trials. breakpoints are discriminatory antimicrobial concentrations used in the interpretation of results of susceptibility testing to define isolates as susceptible, intermediate or resistant.
Updated 2005January 2005 1 Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests Alasdair P. MacGowana* and Richard Wiseb aDepartment of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB; bDepartment of Microbiology, City Hospital NHS Trust, Birmingham …
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