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Establishing MIC breakpoints and the interpretation of in ...
Updated 2005 January 2005 1 Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests Alasdair P. MacGowana* and Richard Wiseb aDepartment of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB; bDepartment of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK Corresponding author: Tel: 0117 959 5652; Fax: 0117 959 3154; Email: The purpose of undertaking susceptibility testing, by whatever method, is to attempt to integrate the drug potency against a population of potential pathogens with the pharmacokinetics of the antimicrobial and, whenever possible, to review this relationship in the light of clinical experience following therapy in clinical trials.
Updated 2005January 2005 2 Introduction The need to know whether an organism is likely to respond to antimicrobial therapy is as old as chemotherapy itself, and the background has been covered in this Supplement by Wheat. 1 A number of mechanisms exist by which one may establish the breakpoint between a susceptible
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