Transcription of EVALUATION OF DRUG-EXCIPIENT INTERACTION IN THE ...
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EVALUATION OF DRUG-EXCIPIENT INTERACTION IN THE ...
Acta Poloniae Pharmaceutica drug Research, Vol. 68 No. 3 pp. 423 433, 2011 ISSN 0001-6837 Polish Pharmaceutical SocietyInteraction between drugs and excipients canalter stability and bioavailability of drugs, thereby,affecting its safety and/or efficacy (1). The success-ful formulation of a stable and effective solid dosageform depends on the careful choice of the excipients (2). The pharmaceutical development of soliddosage forms should imply a previous preformula-tion study of the drug and excipients (3). A numberof experimental techniques ( , DSC, FT-IR spec-troscopy, X-ray powder diffraction, ScanningElectron Microscopy, High Performance LiquidChromatography (HPLC), etc.) have been used toinvestigate the INTERACTION between drug and excipi-ents (4, 5). These analyses can be applied to provideinformation on physicochemical properties of sub-stances with respect to compatibility by predictingfuture problems of stability prior to the final soliddosage formulation (6).
Evaluation of drug-excipient interaction in the formulation of celecoxib tablets 425 obtain 692 mg tablets. The resistance to crushing of tablets was 68 ± 1.5 N.
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