Transcription of ORGANIC SOLVENTS IN THE PHARMACEUTICAL INDUSTRY - …
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ORGANIC SOLVENTS IN THE PHARMACEUTICAL INDUSTRY - …
Acta Poloniae Pharmaceutica Drug Research, Vol. 67 No. 1 pp. 3 12, 2010 ISSN 0001-6837 Polish PHARMACEUTICAL SocietyOrganic SOLVENTS are constantly present in thepharmaceutical production processes. The pharma-ceutical INDUSTRY is one of the largest users of organ-ic SOLVENTS per amount of the final product (1). Theyare usually used at any step of the synthesis pathwayof an active substance or excipients, and sometimesduring the drug product formulation of some physical and chemical barriers, ORGANIC SOLVENTS cannot be completely eliminatedfrom the product by manufacturing practices, suchas drying in an elevated temperature underdecreased pressure or by lyophilization (freeze-dry-ing).
Organic solvents in the pharmaceutical industry 5 tical form, some elemental stages have to be per-formed: (a) synthesis of an Active Pharmaceutical
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