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Evidence-based Practice Center Systematic Review Protocol ...

Source: Published online: June 10, 2013 1 Evidence-based Practice Center Systematic Review Protocol Project Title: vitamin D and calcium : A Systematic Review of Health Outcomes I. Background and Objectives for the Systematic Review The Institute of Medicine (IOM) establishes Dietary Reference Intakes (DRIs), nutrient reference values based on current knowledge about the roles of the various nutrients in human health. The DRIs which comprise estimated average requirements (EARs), adequate intakes (AIs; set in the absence of sufficient evidence to set an EAR), and upper limits (ULs; the highest level of intake likely to pose no health risk to most individuals) form the basis of dietary guidance for the United States and Canada.

What is the effect of vitamin D intake or combined vitamin D plus calcium intake (but not calcium intake alone) on clinical outcomes, including cardiovascular diseases, cancer, immune function, pregnancy or birth outcomes, mortality, fracture, renal outcomes, and soft tissue

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