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Feature ArticlesDoes dopamine administration in shock influence outcome?Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP)Study*Yasser Sakr, MB, BCh, MSc; Konrad Reinhart, MD, PhD; Jean-Louis Vincent, MD, PhD, FCCP;Charles L. Sprung, MD; Rui Moreno, MD, PhD; V. Marco Ranieri, MD; Daniel De Backer, MD, PhD;Didier Payen, MDThe optimal adrenergic supportin shock is controversial. Do-pamine and norepinephrineare the most commonly usedagents to restore tissue perfusion pres-sure in these conditions. Although dopa-mine is the natural precursor of norepi-nephrine, and both combine - and -adrenergic properties, they are differ-ent molecules and have different pharma-cologic profiles.

well as the antibiotics administered. A daily evaluation of organ function that was based on a set of laboratory and clinical variables ac-cording to the Sequential Organ Failure As-

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