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Feature Articles duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*. Anand Kumar, MD; Daniel Roberts, MD; Kenneth E. Wood, DO; Bruce Light, MD; Joseph E. Parrillo, MD;. Satendra Sharma, MD; Robert Suppes, BSc; Daniel Feinstein, MD; Sergio Zanotti, MD; Leo Taiberg, MD;. David Gurka, MD; Aseem Kumar, PhD; Mary Cheang, MSc Objective: To determine the prevalence and impact on mortal- tension was associated with a survival rate of Each hour ity of delays in initiation of effective antimicrobial therapy from of delay in antimicrobial administration over the ensuing 6 hrs initial onset of recurrent/persistent hypotension of septic shock. was associated with an average decrease in survival of By Design: A retrospective cohort study performed between July the second hour after onset of persistent/recurrent hypotension , 1989 and June 2004. in-hospital mortality rate was significantly increased relative to Setting: Fourteen intensive care units (four medical, four sur- receiving therapy within the first hour (odds ratio ; 95%.))

Feature Articles Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

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