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Five Stages of Evolving -Cell Dysfunction During ...
five Stages of Evolving -Cell Dysfunction During progression to diabetes Gordon C. Weir and Susan Bonner-Weir This article proposes five Stages in the progression of diabetes then progress to the IFG or IGT range, where they diabetes , each of which is characterized by different may remain for years before developing frank diabetes . changes in -cell mass, phenotype, and function. stage 1 Although this progression is mostly discussed in the is compensation: insulin secretion increases to maintain context of type 2 diabetes , very similar changes occur as normoglycemia in the face of insulin resistance and/or type 1 diabetes unfolds and as pancreas or islet transplants decreasing -cell mass. This stage is characterized by fail. maintenance of differentiated function with intact We propose that there are five Stages in the progression acute glucose-stimulated insulin secretion (GSIS).
Five Stages of Evolving -Cell Dysfunction During Progression to Diabetes Gordon C. Weir and Susan Bonner-Weir This article proposes five stages in the progression of diabetes, each of which is characterized by different changes in -cell mass, phenotype, and function. Stage 1 is compensation: insulin secretion increases to maintain
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