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Formulation and Evaluation of Sustained Release …
_____ *Corresponding author: Email: British Journal of pharmaceutical Research 1(2): 29-45, 2011 SCIENCEDOMAIN international Formulation and Evaluation of Sustained Release Matrix Tablets of Metformin Hydrochloride Using pH Dependent and pH Independent Methacrylate Polymers Kamlesh J. Wadher1*, Rajendra B. Kakde2 and Milind J. Umekar1 1 Department of pharmaceutical Technology, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur - 441002, India 2 Department of pharmaceutical Sciences, Nagpur University, Amravati Road, Nagpur - 440033, India. Received 24th February 2011 Accepted 28th March 2011 Online Ready 8th April 2011 ABSTRACT Metformin hydrochloride is recommended globally as first line therapy due to its favorable profile on morbidity and mortality associated with type-2 diabetes mellitus.
British Journal of Pharmaceutical Research, 1(2): 29-45, 2011 33 was measured by vernier caliper. Drug content was analyzed by measuring the absorbance
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