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Formulation development and evaluation of gabapentin ...

Submit Manuscript | : API, active pharmaceutical ingredient; MEC, minimum effective concentration; CRDDS, controlled release drug delivery system; MSC, maximum safe concentration; PHN, post herpetic neuralgia; RH, relative humidity; HPMC, hydroxy propyl methyl cellulose; mg, milli gram; gm, grams; ICH, the international conference on harmonization; USP, united states pharmacopeia; NA, not applicable; SR, sustained release; IR, immediate releaseIntroductionImmediate release/Conventional release tablets achieve a rapid onset of action, once they reach the Maximum Effective Concentration; they start to get eliminated from the body. Controlled release tablets of gabapentin are often prescribed for chronic, severe neuronal pain caused as a result of certain long standing diseases. Controlled release tablets are used for a prolonged duration of action with minimal therapeutic effect. They are formulated with natural high intense polymer to achieve sustained release of the Controlled release tablets are formulated with a loading dose and a maintenance The loading dose gives an immediate plasma concentration of the API to have immediate effect and the maintenance dose maintains the level of the drug in the plasma for the gabapentin is generally used as an anti-convulsant and an analgesic.

Submit Manuscript | http://medcraveonline.com Abbreviations: API, active pharmaceutical ingredient; MEC, minimum effective concentration; CRDDS, controlled release ...

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