Solid dispersions as a formulation strategy for poorly ...

1 Solid dispersions as a formulationstrategy for poorly soluble compoundsG. Van den MooterUniversity of Leuven, Belgium20thAnnual Symposium of the Finish Society of Physical PharmacyVithi, Finland 28-29 January 20092 Outline- Introduction: 1. General view on the solubility problem2. formulation strategies for class II compounds- Rationale for using Solid dispersions - Physical structure of Solid dispersions - Carriers in the formulation of Solid dispersions - Analysis of the physical structure- Preparation of Solid dispersions - Advantages and disadvantages of Solid dispersions3 Introduction:general view on the solubility problemOral deliveryis preferred route for drug administrationCandidates for oral drug delivery:adequate solubility / dissolution propertiesadequate absorption through the gutmetabolic stability and no effluxHigh number of all development candidates fail due to biopharmaceutical reasonsPoor physicochemical properties (solubility/dissolution)account for the majority of these failures (ca.)

1 Solid dispersions as a formulation strategy for poorly soluble compounds G. Van den Mooter University of Leuven, Belgium 20th Annual Symposium of the Finish Society of Physical Pharmacy Vithi, Finland 28-29 January 2009

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  Strategy, Soluble, Formulation, Dispersion, Poorly, Dispersions as a formulation strategy, Dispersions as a formulation strategy for poorly soluble

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