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GeneXpert Technology - Molecular Tuberculosis

GeneXpert Technology Indira Soundiram 2012 2010 Cepheid 2 A Better Way to Platform Design GX-I GX-XVI GeneXpert Infinity-48 GeneXpert Module GX-II GX-IV 2010 Cepheid 3 Defining Molecular Diagnostics The GeneXpert Family of Systems GeneXpert Module GeneXpert Cartridge SmartCycler Tube SmartCycler System ICORE Module Any Test Any Time Any Sample Any Place 2010 Cepheid 4 Delivering A Better Way EASY To Use FAST Answers ACCURATE Results Delivering a Better Way to Realize the Benefits of Molecular Diagnostics 2010 Cepheid 5 GeneXpert Dx System Components GeneXpert System includes: Modules Thermal and optical system Cartridge Self-Contained Disposable Computer System Software Barcode scanner Optional Accessories Printer UPS 2010 Cepheid 6 GeneXpert Technology Integrated micro-fluidic based system comprised of Instrument platform Cartridges Protocols and Controls 2010 Cepheid 7 GeneXpert Technology Employ random access fluidic systems that bridge microfluidics with macro fluidics Uses multiplex, rapid real-time PCR technique (6-colors) Precision of microfluidics-based reconstitution, and simplification of automated filling Exploits proven SmartCycler Technology (Incorporate same solid-state thermal cycler/fluorometer module) Utilize families of cartridges to address wide range of applications and specimen types 2010 Cepheid 8

8 © 2010 Cepheid No wet interface between instrument and cartridge to eliminate carry-over Integrated ultrasonic horn for rapid lysis of spores Total internal ...

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