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Guide to achieving reliable quantitative LC-MS measurements Guide to achieving reliable quantitative LC-MS measurements RSC Analytical Methods Committee First Edition 2013 Editor Mike Sargent Contributors Ashley Sage Celine Wolff Chris Mussell David Neville Gwyn Lord Mansoor Saeed Rakesh Lad Ruth Godfrey Simon Hird Vicki Barwick Acknowledgements This Guide has been prepared with the assistance of members of the AMC mass Spectrometry Sub-Committee. Publication of the draft Guide with minor corrections was approved by the AMC at its meeting on 15 November 2013. Production of this Guide was in part funded by the UK National Measurement System. We are grateful to Agilent Ltd for permission to reproduce Figures , and Gareth Brenton for Figure This publication should be cited as: M.
Quantitative LC-MS Guide, 1st Ed. 2013 Page i Preface Mass spectrometry (MS) has the capability to separate organic molecules according to their molecular mass and permits their detection and quantitation with extremely high sensitivity.
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