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Highly active antiretroviral therapy (HAART) in adults ...

INT J TUBERC LUNG DIS 9(3):248 257 2005 The UnionHighly active antiretroviral therapy (HAART) in adults with tuberculosis: current status*A. Kwara, T. P. Flanigan, E. J. CarterSUMMARYD epartment of Medicine, Miriam Hospital/Brown Medical School, Providence, Rhode Island, USAThe overlapping epidemiology of human immunodefi-ciency virus (HIV) infection and tuberculosis (TB) andthe catastrophic consequences of the interactions betweenthe two epidemics have led to increased morbidity andmortality due to HIV-associated TB. While effective ther-apy is available for both conditions, there are majorchallenges in the concurrent treatment of HIV and TB co-infection. This review examines the interactions betweenHIV and TB infections and reviews the current status ofhighly active antiretroviral therapy (HAART) in patientswith co-infection.

250 The International Journal of Tuberculosis and Lung Disease PIs and NNRTIs and the rifamycins, key components of combination therapy for HIV and TB disease, re-spectively, severely limit the …

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