Transcription of International Consensus (ICON) - EAACI.org
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International Consensus (ICON) - EAACI.org
International Consensus (ICON) on drug AllergyAllergy 2014; 69: 420 437 Pascal Demoly, N. Franklin Adkinson, Knut Brockow, Mariana Castells, Anca M. Chiriac, Paul A. Greenberger, David A. Khan, David M. Lang, Hae-Sim Park, Werner Pichler, Mario Sanchez-Borges, Tetsuo Shiohara, Bernard Yu-Hor summary was drafted by Dr Rik Schrijvers and Dr Anca M. Chiriac under the supervision of Professor Pascal to Dr Rik Schrijvers and Dr Anca Mirela Chiriac, 2 EAACI JMAs and FS recipients, for their precious help for this extensive of contents4 PREFACE4 DEFINITIONS 5 CLASSIFICATIONS6 PATHOPHYSIOLOGY7 CLINICAL PRESENTATIONS8 NATURAL HISTORY8 DIAGNOSIS10 CLINICAL HISTORY11 SKIN TESTS 12 drug PROVOCATION TESTS13 BIOLOGICAL TESTS14 MANAGEMENT15 LIST OF ABBREVIATIONS4 PREFACEDrug hypersensitivity reactions (DHRs) comprise all drug reactions resembling allergy.
6 Mechanistically: DHRs can be defined as allergic (Table) and non-allergic: PATHOPHYSIOLOGY Drug allergies are adverse reactions whereby antibodies and/or activated T-cells are directed against the drugs or against one of its metabolites.
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