Transcription of Introduction to Avian Influenza - Iowa State …
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Introduction to Avian Influenza - Iowa State …
Introduction to Avian InfluenzaDavid L. Suarez , Leader Exotic and Emerging Avian Viral Disease Research UnitAgricultural Research ServiceUnited States Department of AgricultureHAPB1PB2 PANPNAMANSM2 HemagglutininNeuraminidaseM1 Influenza A VirusNegative sense RNA Single strandedSegmented16 Hemagglutinin subtypes9 Neuraminidase SubtypesInfluenza NomenclatureA/Chicken/Pennsylvania/1370/ 83 (H5N2)1 2 3 4 5 6 71) Antigenic type2) Isolate host of origin3) Geographic location4) Isolate reference5) Year of isolation6) Hemagglutinin subtype7) Neuraminidase subtype Influenza Subtypes 16 Hemagglutinin subtypes 9 Neuraminidase subtypes 2 Nonstructural subtypes Can occur in any combination Useful for epidemiologyWhat Defines a Subtype? Neutralizing antibody produced against one virus will neutralize all other viruses of the same subtype A different subtype is defined when neutralizing antibody produced for one subtype will not neutralize viruses from other subtypes Subtypes are defined by antigenic characteristics of the virus Virus isolates will occasionally cross react with more than one reference antibodies Hemagglutination inhibit
Introduction to Avian Influenza David L. Suarez D.V.M., Ph.D. Research Leader Exotic and Emerging Avian Viral Disease Research Unit Agricultural Research Service
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