Transcription of Introduction to Quantitative Genetics - mun.ca
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Introduction to Quantitative Genetics - mun.ca
1/29/2014, 12:41 PMQuantitative GeneticsPage 1 of 2 to Quantitative GeneticsIn principle:We can extend single-locus multilocus Quantitative models1AA : 2Aa : 1 aa (1 AnAn : 2 Anan : 1anan)n normal distributionGenotype / Phenotype correlation Heritability Genotypic expression depends on environment Heritability (h2) estimates proportion of phenotypic variation due to genetic variation "Is It genetic ?" : Genotype / Environmental interaction is variable (& unpredictable) The Norm of Reaction describes thisHeritability is not inevitability; Genetics is not destinyVariation can be quantified (review) mean standard deviation: variance: 2 Variation follows "normal distribution" (bell-curve) iff Multiple loci are involved ( Quantitative ) Each locus has about equal effect (additive) Each locus acts independently [interaction variance (see below) is minimal] Ex.
For many quantitative traits in many organisms: h2 = 0.5 ~ 0.9 Heritability is typically calculated in a single environment. The Norm of Reaction mediates genotype through environment to produce phenotype
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