Transcription of Ion Trap Mass Spectrometry - Current Separations
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Ion Trap Mass Spectrometry - Current Separations
mass Spectrometry , the science andtechnology of gaseous ions (1), hasas its basis the measurement ofmass-to-charge ratios (m/z) of atomic and molecular ions are,in principle, accessible by massspectrometry, making it a universalmethod for chemical analysis. Itsimplementation requires suitablemethods of ion generation, ionanalysis, and ion detection. We treateach of these processes in turn andshow below that there are multiplemethods of accomplishing first step in recording amass spectrum is to convert analytemolecules (or atoms) into gas phaseions. In biological applications, themost common ionization tech-niques are electrospray ionization(ES) (2), atmospheric pressurechemical ionization (APCI) (3,4),and matrix-assisted laser desorptionionization (MALDI) (5). These aresoft ionization methods in the sensethat at least some analyte moleculesare converted, intact, into corre-sponding ions.
LC/MS technique. These combina-tions have been used, for example, in organic analysis in the environ- ... ture of an ion trap is that MS/MS experiments are possible. Even when compared with a triple quad-rupole MS/MS instrument, the ion trap …
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