Lecture 11 - Biosynthesis of Amino Acids
pentose phosphate pathway. The L–stereochemistry is enforced by transamination of α–keto acids Introduction. 5 Text ... 3–Phosphoglycerate dehydrogenase is inhibited by serine. 3. Regulation of Amino Acid Biosynthesis. 38 Text Example: Serine biosynthesis 3–Phosphoglycerate dehydrogenase 3. Regulation of Amino Acid
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Structure and Mechanism of Alkaline Phosphatase
www.chem.uwec.eduSTRUCTURE AND MECHANISM OF ALKALINE PHOSPHATASE Joseph E. Coleman ... CONCLUSIONS ON STRUCTURE AND MECHANISM OF ALKALINE PHOSPHATASE DERIVED ... (66, 67). The amino acid sequences of the mammalian enzymes, derived from their cDNA sequences, can be fit into the primary structure of the bacterial enzyme, with the proper adjustments for some ...
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www.chem.uwec.eduB. Obtaining structural information about proteins using FTIR spectroscopy FTIR spectroscopy provides information about the secondary structure content of proteins, unlike X-ray crystallography and NMR spectroscopy which provide information about the tertiary structure. FTIR spectroscopy works by shining infrared radiation on a
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www.chem.uwec.edu• Quick recovery times after surgery 1.2.9 Introducing chemically susceptible groups N CH 2 C O O MeO OMe H MeO (CH)5O C OMe O CH Me MeO OMe OMe OMe 1.2 Drug stability. ... Trojan horse tactic 1.3.1 Linking a biosynthetic building block 1.3 Drug targeting Non selective alkylating agent Toxic N Cl Cl H 3C Uracil Mustard H N HN O O N Cl Cl.
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www.chem.uwec.eduevolved on earth Chem 452, Lecture 1 - Introduction to Biochemistry Biology is Varied and Complex 8 At the molecular level, living systems look remarkably similar. This similarity is a reflection of how life evolved on earth Chem 452, Lecture 1 - Introduction to Biochemistry Biology is Varied and Complex 8 At the molecular level, living systems
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www.chem.uwec.eduThe interaction of a drug with a receptor can produce a range of different types of effects. The types of interactions that can occur are shown graphically below. Drugs that bind to a receptor and mimic the effect of the endogenous ligand are called agonists. If a drug produces less than a full effect even at doses that saturate the
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www.chem.uwec.edub. What is the turnover number for Hexokinase under these conditions? # turnover number = k cat= V max [E]total = 186 µmol mL•s 3.0 nmol mL = 186x10−6 mol 3.0x10−9 mol mL =62,000/s c. What is the catalytic efficiency for Hexokinase under these conditions? # catalytic efficiency = k cat K M = 62,000/s 3.0x10−4 M =2.1 x 108/(M•s) d. Does Hexokinase display “catalytic …
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