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Long Term Oxygen Therapy (LTOT)

National Lung Health Education Term OxygenTherapy (LTOT)History, Scientific Foundations, andEmerging TechnologiesThomas L. Petty, W. McCoy, , RRTD ennis E. Doherty, Oxygen Consensus Conference RecommendationsHistorical HighlightsPage 2 physiologic Responses to LTOT Page 3 Two Major Randomized Clinical TrialsPage 5 The British Medical Research Council Clinical TrialThe Nocturnal Oxygen Therapy Trial (NOTT)Other Benefits from OxygenPage 7 Oxygen Dosing (Liter Flow)Page 7 Prescribing CriteriaPage 8 Oxygen ToxicityPage 9 Oxygen SafetyPage 10A Re-Examination of the Nocturnal Oxygen Therapy Trials (NOTT)Page 10 Oxygen TechnologiesPage 15 Cost Effectiveness of LTOTPage 21 The National Lung Health Education Program (NLHEP)Page 22 Appendix: Recommendations of the Six Oxygen Consensus Conferences (2006, 1999, 1993, 1990, 1987, 1986)Page 24 ReferencesPage term Oxygen Therapy (LTOT) is well established as the standard of care for manypatients with chronic stable hypoxemia.

Historical Highlights Page 2 Physiologic Responses to LTOT Page 3 Two Major Randomized Clinical Trials Page 5 The British Medical Research Council Clinical Trial

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  Terms, Response, Therapy, Long, Oxygen, Long term oxygen therapy, Physiologic, Physiologic responses

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