Laboratory Diagnosis of Hemoglobinopathies and Thalassemia

Diagnosis • Indications for Testing – Hemolytic anemia; family history of hemoglobinopathy • Laboratory Testing – Initial testing – CBC with peripheral smear – Polychromasia, spherocytes, schistocytes, sickle cells, Heinz bodies, basophilic stippling; however, the lack of any of these cells does not rule out hemolytic anemia

  Laboratory, Diagnosis, Laboratory diagnosis of

Method Validation and Verification - University of Utah

Feb 12, 2018 · • Precision, accuracy, reportable range and reference interval must be evaluated, at a minimum, for all nonwaived tests before patient use • No “one size fits all” approach to validation/verification 41

  Validation, Precision, Accuracy

Resolution of ABO Discrepancies

4+0 A1 Cell B Cell 1+ Lectin Patient’s Cells D. biflorus 0 Antibody Screen I.S. (RT) AHG Check Cells Screening Cell 1 0 0 Screening Cell 2 0 0 Screening Cell 3 0 0 Auto Control 0 0 Forward Type Reverse Type Most Anti-A reagents react strongly with A2 Cells Unexpected Reactivity with A1 Cells No unexpected antibodies detected

  Creativity

Cytogenetics Lecture 1: Introduction to Clinical Cytogenetics

Cell Division and The Cell Cycle •Mitosis: division of somatic cells •Meiosis: division of gametic cells •Cell cycle: 4 phases: Mitosis (M), Gap1 (G1), Synthesis (S), Gap2 (G2) NCBI Bookshelf: Cooper, The Cell: A Molecular Approach, 2nd Ed 2000

  Cells, Somatic

HYPOCELLULAR BONE MARROW… WHAT’S NEXT?

DNA damage response pathway 1. CORE COMPLEX: 8 wild type proteins ‘FANC’ (A,B,C,E,F,G,L,M) and 4 additional proteins FAAP (16,20,24,100) 2. ID COMPLEX: two downstream proteins FANC I and D2 3. DOWNSTREAM EFFECTOR COMPLEX: 5 other proteins: FANCD1, BRCA2, FANCJ, BACH1, and BRIP1 21 known FA subtypes 1 •Mutation of …

Kidney Stones: Diagnosis, Treatment, & Future Prevention

Describe the clinical presentation, laboratory, and radiographic findings of an individual affected by a kidney stone. 2. Compare 3 composition types of kidney stones and their clinical management. 3. Differentiate spontaneous and familial risk factors for kidney stone development.

  Presentation

Microscopy of CSF & Body Fluids - University of Utah

Microscopy of CSF & Body Fluids May 13, 2019 Professor of Pathology University of Utah Health Executive Director, Clinical Trials & PharmaDx ARUP Laboratories

Diagnosis of Monoclonal Gammopathies

–Protein Electrophoresis • Serum • Urine –Immunofixation • Free light chain ratio assay Outline. Serum protein electrophoresis (sPEP) •Intended for the separation of human serum proteins •Divides proteins in five major fractions: albumin, alpha-1, alpha-2, beta and gamma .

  Protein, Serum, Electrophoresis, Serum protein electrophoresis, Protein electrophoresis

Chapter 1 Overview of Hematologic Malignancies

achieved in patients with Hodgkin lymphoma, treatment toxicities remain a significant source of morbidity and mortality for survivors of this disease (Hoppe, 1997). The most commonly noted causes of mortality are second malignant neoplasms and cardiovascular disease (Hoppe, 1997). While mortality from Hodgkin lymphoma be-

  Neoplasm, Lymphoma, Hodgkin, Hodgkin lymphoma

NATIONAL INSTITUTES OF HEALTH National Cancer Institute

ICD-O-3 has been updated to include contemporary terminology. For example, the non-Hodgkin lymphoma section is now based on the World Health Organization Classification of Hematopoietic Neoplasms3. In the process of revising the morphology section, a Field Trial version was published and tested in both the United States and Europe.

  Lymphoma, Hodgkin, Hodgkin lymphoma

USMLE Content Outline

associated lymphoid tissue and bronchus-associated lymphoid tissue), anatomical locations of T and B lymphocytes . Cellular basis of the immune response and immunologic mediators . antigen processing and presentation in the context of MHC I and MHC II molecules (eg, TAP, beta-2 microglobulin), intracellular pathways, mechanisms by which MHC is

  Outline, Content, Usmle, Usmle content outline, Lymphoid