Transcription of Membrane lipid composition and cellular function
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Membrane lipid composition and cellular function
L e I. Membrane lipid composition and cellular function Arthur A. Spector and Mark A. Yorek Departments of Biochemistry and Internal Medicine, University of Iowa, Iowa City, IA 52242. Abstract Membrane fatty acid composition , phospholipid in the bilayer can modulate the activity of Membrane composition , and cholesterol content can be modified in many proteins. different kinds of intact mammalian cells. The modifications are At the time that the fluid mosaic model was formulated, extensive enough to alter Membrane fluidity and affect a number of cellular functions, including carrier-mediated transport, the evidence was becoming available that Membrane lipids properties of certain Membrane -bound enzymes, binding to the can influence the function of certain Membrane proteins. insulin and opiate receptors, phagocytosis, endocytosis, depolar- For example, it already was known that when human ization-dependent exocytosis, immunologic and chemothera- erythrocyte membranes were exposed to phospholipase A*, peutic cytotoxicity, prostaglandin production, and cell growth.
l e I Membrane lipid composition Arthur A. Spector and Mark A. Yorek and cellular function Departments of Biochemistry and Internal Medicine, University of Iowa, Iowa City, IA 52242 Abstract Membrane fatty acid composition, phospholipid
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