Transcription of Neurobiological Mechanisms of Social Anxiety Disorder
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1558Am J Psychiatry 158:10, October 2001 Reviews and OverviewsNeurobiological Mechanisms of Social Anxiety DisorderSanjay J. Mathew, D. Coplan, M. Gorman, : The authors critically surveyedseveral preclinical and clinical neurobio-logical models of Social Anxiety : The authors reviewed the recentliterature regarding three animal modelsof particular relevance to Social then examined the recent literatureconcerning clinical Neurobiological aspectsof Social Anxiety Disorder , including the de-velopmental neurobiology of Anxiety , thegenetics of fear and Social Anxiety , andchallenge and imaging : The available animal models areuseful paradigms for understanding thefeatures of Social subordination stress, at-tachment behavior, and environmentalrearing, but they incompletely account forthe known neurobiology of human socialanxiety Disorder .
neurobiology toward a trait-like socially anxious profile. Clinically, however, the neuroendocrine findings of disso- ciation between increased CRF levels and decreased corti-
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