Transcription of New MHRA recommendations on simvastatin interactions ...
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New MHRA recommendations on simvastatin interactions ...
ABHB Medicine Management team contact details at September 2012 Page 1 of 2 New MHRA recommendations on simvastatin interactions implications for patients taking AMLODIPINE & simvastatin 40mg/day The August 2012 edition of the MHRA s Drug Safety Update (vol 6, issue 1)1 highlights updated contraindications and dose recommendations for simvastatin when used with a number of other medicines. These changes have been driven by concerns over the risks of myopathy and/or rhabdomyolysis at higher plasma concentrations of simvastatin . A full updated listing of all the interactions is provided in table 1 overleaf. Key points to note are that: simvastatin is now contraindicated with ciclosporin, danazol and gemfibrozil The maximum recommended dose for simvastatin in conjunction with amlodipine or diltiazem is now 20 mg/day 2 As amlodipine and simvastatin 40mg/day are widely co prescribed in Gwent the following advice has been issued by ABHB Medicines Management for patients on this combination: 1.
ABHB Medicine Management team contact details at http://www.wales.nhs.uk/sites3/page.cfm?orgid=814&pid=62124 September 2012 Page 1 of 2 New MHRA recommendations on ...
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