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Nutrition in childhood - Royal Children's Hospital

FRACP lecture series Nutrition in childhood Ralf G. Heine MD FRACP. Dept. of Gastroenterology & Clinical Nutrition Royal Children's Hospital , Melbourne Importance Importance of of adequate adequate Nutrition Nutrition !Growth !Brain development !Tissue repair !Immune system !Metabolism Incidence of acute protein-energy malnutrition in hospitalised children " < 3 months 63%. " 3 - 12 months 73%. " 1 - 5 years 38%. " 6 - 12 years 41%. " 13 - 18 years 44%. J Pediatr Surg 1981;16:554. Clinical consequences of malnutrition " Loss of muscle strength : skeletal, respiratory " Increased incidence of fractures " Increase in pressure sores " Delayed wound healing " Impaired immune function " Impaired hormone function " Impaired thermoregulation " Impaired cardiovascular and gastrointestinal function " Depression/apathy " Increase in post-surgical complications Adverse Adverse effects effects of of catabolic catabolic state state # Negative nitrogen balance # Muscle wasting # Weakness # Respiratory muscle failure Fluid Fluid maintenance requirements requirements Body weight Daily fluid volume Hourly rate 0 10 kg 100 mls/kg 4 mls/kg 10 20 kg 1000 ml

Low-birth weight infantsLow-birth weight infants " Birth weight < 2500g - Western countries 7% - Developing world 40% " Upper and lower respiratory infections 3 times more frequent " Decreased levels of maternal IgG (placenta) " Thymic atrophy and impaired cellular immunity " Reduced thymopoetin levels " Decreased number of T-lymphocytes " Persists for several months or …

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