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ORAL CHELATION THERAPY FOR PATIENTS WITH LEAD …

1 ORAL CHELATION THERAPY FOR PATIENTS WITH LEAD POISONING Jennifer A. Lowry, MD Division of Clinical Pharmacology and Medical Toxicology The Children s Mercy Hospitals and Clinics Kansas City, MO 64108 Tel: (816) 234-3059 Fax: (816) 855-1958 December 2010 2 TABLE OF CONTENTS 1. Background of Lead Poisoning ..3 a. Clinical Significance of Lead Measurements ..3 b. Absorption of Lead and Its Internal Distribution Within the Body ..3 c. Toxic Effects of Exposure to Lead in Children and Adults ..4 d. Reproductive and Developmental e. Mechanisms of Lead Toxicity ..6 f. Concentration of Lead in Blood Deemed Safe for g. Use of Blood Lead Measurements as a Marker of Lead Exposure ..7 2. Management of the Child with Elevated Blood Lead Concentrations.

5 and present as a microcytic anemia. Anemia in lead poisoning results from impairment of hemoglobin production and changes in the red blood cell membrane.

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  Therapy, Hemoglobin, Chelation therapy, Chelation, Of hemoglobin

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