Transcription of ORIGINAL ARTICLE Assessment of the human Cell …
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ORIGINAL ARTICLE Assessment of the human Cell …
Takao Ashikaga et al, AATEX 13(1), 27-35, 2008 27 Introduction Because of increasing social concern about animal welfare and the use of animals in testing, many alternative, non-animal tests have been proposed. There is particular interest in developing alterna-tive methods for skin sensitization testing (De Silva et al., 1996). Measuring phenotypic changes, such as CD86 or CD54 expression on dendritic cells, induced by sensitizers is an important ap-proach for developing alternative methods of evaluating skin sensitization potential (Aiba et al., 1997; Hopper et al., 1995). However, the effects of chemicals on the surface phenotype of dendritic cells are dependent on the source of peripheral blood used to obtain the cells; in other words, the effect varied from donor to donor (Aiba et al.)
Ashikaga T et al, Assessment of the human Cell Line Activation Test (h-CLAT), AATEX 13(1), 27-35, 2008 29 dicator of CD86 and CD54 expression and was
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