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Nova Acta Leopoldina NF 112, Nr. 382, 11 16 (2011)11 Population-Based Studies are Necessary toStudy the Effect of Intrauterine Life Wolfgang Hoffmann and Jochen Ren Thyrian (Greifswald) With 1 FigureAbstractEpidemiological research is important to describe and explain the developmental origins of health and disease, including genetics, environment, behaviour and time. Systematic evidence underlines the importance and the inter-dependence of the determinants. However, the key challenge for public health is prevention. To achieve this goal the research agenda must identify (i) causal mechanisms, (ii) supporting or hindering factors of the environment and the individual, (iii) vulnerable/ sensitive phases of the individual and (iv) trajectories over time. In our view prospective population based cohort and intervention Studies like the SNiP- Study provide the most promising way to meet this complex epidemiologische Forschung ist von gro er Bedeutung f r die Beschreibung und Analyse der Entstehung von Gesundheit und Krankheit in der kindlichen Entwicklung, einschlie lich Genetik, Umwelt, Verhalten und Zeit.
Population-Based Studies are Necessary to Study the Effect of Intrauterine Life Nova Acta Leopoldina NF 112, Nr. 382, 11–16 (2011) 13 13 million deaths per year (Pruss-Ustun et al. 2008).
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