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Prolotherapy: Basic Science, Clinical Studies, and …

prolotherapy (growth factor or growth factorstimulation injection) raises growth factor levels oreffectiveness to promote tissue repair or factors are complex proteins (polypep-tides), and their beneficial effects on human liga-ment, tendon, cartilage, and bone are under intenseinvestigation. prolotherapy may utilize inflamma-tory or noninflammatory TENDON AND LIGAMENTHEALINGTo understand prolotherapy , a knowledge of thepathology of sprain or strain and the normal healingprocess is necessary. Sprains (ligaments) and strains(tendons) become chronic when healing does notresult in sufficient tensile strength or ,50 This condition also is termed connective tissue in-sufficiency(CTI), in which the structure is either tooloose or has insufficient tensile in CTI stimulates pain et al.

PROLOTHERAPY: BASIC SCIENCE, CLINICAL STUDIES, AND TECHNIQUE 173 growth factor to work, it needs to be produced, ap …

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